Through this test, you’ll gain insights into how your genetics influence critical aspects of your health, including heart function, weight management, mental wellbeing, nutrient absorption, and drug metabolism. You’ll receive a personalised report highlighting how your DNA impacts your overall wellness, along with practical recommendations tailored to your results.
Unlike generic DNA tests, our myDNA Comprehensive Check is conducted by an Australian NATA-accredited laboratory. Results are analysed by our expert team of molecular biologists, data scientists, and clinicians to provide a report that is scientifically accurate and highly actionable. Whether you’re looking to optimise your health or manage specific concerns, this test is your guide to unlocking your genetic potential.
Methylation is one of the most essential processes in our bodies, influencing everything from energy production to detoxification, mental wellbeing, and longevity. Whether you’re struggling with fatigue, mood swings, digestive issues, or inflammation, knowing your methylation profile can help you modify your diet, change your lifestyle, and more effectively supplement to better support your health.
You’ll receive a detailed report describing your individual methylation profile and the implications of this for your health. Based on your methylation profile we’ll provide you with personalised nutrition guidelines and a supplement prescription. Find out more about the different methylation profiles here.
Our Genetic Methylation Check is performed by an Australian NATA accredited laboratory. Your data is managed in accordance with the Australian Privacy Principles (APP) using the latest encryption meaning you can be sure of complete discretion and confidentiality.
The following genes are included within the scope of this test report:
Apolipoprotein E (APOE) is a lipid-binding protein involved in transporting triglycerides and cholesterol, with the APOE-e4 allele being a significant genetic risk factor for Alzheimer’s disease. However, other epigenetic factors also play a significant role.
Apolipoprotein E (APOE) is a lipid-binding protein involved in transporting triglycerides and cholesterol, with the APOE-e4 allele being a significant genetic risk factor for Alzheimer’s disease. However, other epigenetic factors also play a significant role.
Celiac disease is an immune reaction to gluten, a protein in wheat, barley, and rye. While about 30% of people have variants in the celiac risk genes HLA-DQA1 through HLA-DQB, only ~3% develop the condition.
Celiac disease is an immune reaction to gluten, a protein in wheat, barley, and rye. While about 30% of people have variants in the celiac risk genes HLA-DQA1 through HLA-DQB, only ~3% develop the condition.
Mutations in the HFE C282Y gene can cause iron overload by increasing iron absorption and disrupting metabolism. Homozygotes account for most hemochromatosis cases, while those with one mutation have a lower risk but may still benefit from further testing if there’s a family history.
The MTHFR enzyme is essential for processing folate and converting homocysteine into methionine. Individuals with this mutation may have higher homocysteine, though the effects depend on whether they have one or two copies of the mutation.
This mutation can also reduce the efficiency of the MTHFR enzyme. While its impact is typically less severe than the C677T mutation, having one or two copies of A1298C may impact neurotransmitter and hormone production and contribute to oxidative stress.
The LPA I4399M gene variant is a change in the LPA gene that can increase the risk of heart disease by raising levels of a protein called lipoprotein (a), which can lead to the buildup of plaques in arteries.
The PON1 gene encodes paraoxonase 1, an enzyme that protects cells from oxidative damage by attaching to HDL particles. The Q192R mutation alters the enzyme’s efficiency, potentially increasing the risk of heart disease and inflammation.
The PPAR-alpha rs1800206 gene variant is a change in the PPARA gene, which helps regulate how the body uses fats for energy. This variant can affect fat metabolism and influence the risk of developing type 2 diabetes and heart disease.
The APOA2 T-265C gene variant has been associated with differences in body mass index (BMI) and food intake, potentially influencing obesity risk and dietary habits.
This ACSL1 variant is associated with fat metabolism and lipid processing. ACSL1 encodes an enzyme critical for activating long-chain fatty acids, a key step in lipid metabolism. Variants may influence how efficiently the body metabolises and stores fats, potentially affecting energy production and fat distribution.
The GPX1 gene encodes glutathione peroxidase 1, an enzyme that protects cells from oxidative damage. This variant can reduce the enzyme’s efficiency, increasing the risk of oxidative stress-related conditions like diabetes complications and certain cancers.
A COMT mutation can change how quickly your body breaks down dopamine, adrenaline, and noradrenaline – this can affect neurological systems that regulate mood, cognitive function, and stress.
This mutation is associated with lower choline production in the liver. Choline is essential for production of acetylcholine which helps send messages through to various organs, ensuring smooth communication within our nervous system and proper functioning of our organs.
Similar to PEMT C744G, this mutation is also associated with lower choline production in the liver. Both PEMT variations can lead to lower phosphatidylcholine levels, which may increase the risk of fatty liver disease and issues with fat metabolism.
The LCT C-13910T gene variant affects the lactase enzyme, which breaks down lactose. This variant is linked to lactose persistence – the ability to digest lactose. The Wild type variant on the other hand, causes lactose intolerance: difficulty digesting lactose and leading to gastrointestinal symptoms like bloating, gas, and diarrhoea.
This variant affects alcohol metabolism by reducing ALDH2 enzyme activity. Carriers of the A allele accumulate acetaldehyde, causing flushing, nausea, and higher risks of alcohol-related health issues.
The VKORC12 G-1639A gene variant affects how the body processes vitamin K, essential for blood clotting and bone health. This variant can also influence the dosage of blood-thinning medications like warfarin, as it impacts the enzyme’s activity involved in recycling vitamin K.
The CYP2R1 gene, is responsible for converting vitamin D into its active form in the liver. This variant can influence vitamin D levels in the body, with certain alleles associated with lower vitamin D levels and potential vitamin D insufficiency.
MTHFD1 helps convert folate from one form into another which is critical for methylation. Mutations in MTHFD1 may result in lower levels of active folate as well as folate intermediates, which are a key input for crucial making DNA and RNA, and downstream biological pathways.
The methionine synthase enzyme is required to convert homocysteine to methionine. The mutation may reduce enzyme efficiency, potentially contributing to elevated homocysteine levels, especially when combined with other genetic or nutritional factors.
This gene encodes an enzyme essential for regenerating methionine synthase. Similar to MTR, mutations in this gene may impair enzyme function, potentially leading to elevated homocysteine levels.
The FUT2 gene encodes an enzyme that influences blood group antigen secretion and gut bacteria composition. This variant can cause non-secretor status, affecting gut microbiome diversity and nutrient absorption and increasing susceptibility to infections like norovirus and autoimmune disorders.
The TCN2 gene encodes transcobalamin II, which transports vitamin B12 to cells. The G776C variant can lower transcobalamin levels, reducing vitamin B12 availability and potentially increasing the risk of conditions like peripheral neuropathy.
The 5-HT2A gene encodes the serotonin 2A receptor, which regulates mood and responses to medications. The T102C variant can affect responses to psychotropic drugs and is linked to conditions like schizophrenia and depression.
The 5-HT2A gene encodes the serotonin 2A receptor, which regulates mood and responses to medications. The G-1438A variant can influence receptor expression, affecting the response to antipsychotics and increasing the risk of depression.
The MAO-A gene encodes an enzyme that breaks down neurotransmitters like serotonin, norepinephrine, and dopamine. The R297R variant can affect enzyme activity, potentially increasing susceptibility to psychiatric conditions such as depression and anxiety.
The BDNF gene encodes brain-derived neurotrophic factor, essential for neuron growth and survival. The V66M variant can impair BDNF secretion, leading to memory issues, mood disorders, and an increased risk of neuropsychiatric conditions like depression and schizophrenia.
The NBPF3 gene is associated with the synthesis of a hormone involved in the clearance of vitamin B6 from the body. Variants can lead to lower levels of vitamin B6 in the blood, which is important for neurological function, red blood cell production, and sugar metabolism.
The IL-6 gene encodes the cytokine interleukin-6 (IL-6), which plays a key role in inflammation and immune response. The G-174C variant can lead to higher levels of IL-6 in the blood, increasing the risk of inflammatory conditions.
The TNF-a gene encodes TNF-alpha, a cytokine involved in inflammation and immune response. The G-308A variant may increase TNF-alpha production, raising the risk of inflammatory conditions and cardiovascular diseases.
CYP1A2 is responsible for metabolising caffeine, a stimulant found in coffee, tea, and other beverages. Variations in the CYP1A2 gene can influence the rate at which caffeine is metabolised, affecting its duration of action and potential impact on sleep.
The CYP2C9 gene encodes an enzyme involved in the metabolism of various drugs, including warfarin. The A1075C variant (CYP2C93) affects the enzyme’s activity, leading to reduced metabolism of warfarin and an increased risk of bleeding in individuals taking the medication.
The CYP2C19 gene encodes an enzyme involved in the metabolism of various drugs. The C-806T variant (CYP2C1917) increases the enzyme’s activity, leading to ultra-rapid drug metabolism and potentially affecting the efficacy and safety of medications.
The CYP2D6 gene encodes an enzyme involved in the metabolism of many drugs, including antidepressants and opioids. The C100T variant (CYP2D610) can lead to increased enzyme activity, affecting how individuals respond to medications.
The CYP3A4 gene encodes an enzyme involved in the metabolism of many drugs and toxins. The A-392G variant (CYP3A41B) can increase the enzyme’s activity, potentially affecting drug metabolism.
The ADIPOQ gene encodes the protein adiponectin, which helps regulate glucose levels and fatty acid breakdown. The T45G variant can influence adiponectin levels and is associated with insulin resistance and metabolic diseases.
The MTNR1B gene produces a receptor for melatonin, which regulates sleep-wake cycles. Variants in this gene may raise blood sugar levels, increasing type 2 diabetes risk, and can also affect sleep quality, making it harder to fall or stay asleep.
The TCF7L2 gene encodes a transcription factor involved in the Wnt signalling pathway, which plays a role in regulating blood sugar levels. This variant is associated with an increased risk of type 2 diabetes by affecting insulin secretion and glucose metabolism.
The PPARGC1A gene encodes the protein peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), which is a master regulator of mitochondrial biogenesis and energy metabolism. The G482S variant is associated with an increased risk of type 2 diabetes and metabolic diseases.
The SHBG gene produces sex hormone-binding globulin, which regulates sex hormone levels like estrogen and testosterone. Variations in the SHBG gene can affect SHBG levels, influencing the risk of type 2 diabetes and menopausal symptoms, as well as bone health, muscle mass, and overall well-being.
The SHBG gene produces sex hormone-binding globulin, which regulates sex hormone levels like oestrogen and testosterone. Variations in the SHBG gene can affect SHBG levels, influencing the risk of type 2 diabetes and menopausal symptoms, as well as bone health, muscle mass, and overall well-being.
The ACE1 gene encodes the angiotensin-converting enzyme (ACE), which regulates blood pressure and fluid balance. The rs4343 variant (A2350G) is linked to higher ACE levels with the G allele, potentially impacting blood pressure and cardiovascular risk.
The AGTR1 gene encodes the angiotensin II type 1 receptor, which plays a role in regulating blood pressure and fluid balance. The A1166C variant can increase the risk of hypertension and metabolic syndrome by affecting the receptor’s function.
The NOS1 gene encodes neuronal nitric oxide synthase (NOS1), which produces nitric oxide, involved in regulating blood flow and neurotransmission. Variants are associated with an increased risk of developing diabetic nephropathy and an increased likelihood of renal replacement therapy.
The ADRB2 gene encodes the beta-2 adrenergic receptor, which is involved in the body’s response to adrenaline and noradrenaline, affecting heart rate, blood pressure, and metabolism. The G16R variant can influence the receptor’s function and has been associated with conditions like asthma.
The DIO1 gene converts inactive thyroid hormone (T4) into its active form (T3), which regulates metabolism and energy use. Variants can affect this conversion, potentially altering thyroid hormone levels and metabolic balance.
The VDR gene encodes the vitamin D receptor, which regulates calcium and phosphate levels, affecting bone health and immune function. The FokI variant impacts VDR activity, with the GG variant being more active, potentially influencing vitamin D metabolism and related health outcomes.
The ABCG2 gene encodes a protein that transports substances like drugs and toxins in and out of cells. The Q141K variant reduces this transport, leading to a buildup of uric acid in the blood, increasing the risk of gout and affecting kidney health.
The CYP17A2 gene encodes an enzyme involved in producing steroid hormones like oestrogen and androgens. The T-34C variant can increase the activity of this enzyme, leading to higher levels of these hormones and potentially affecting conditions like hormone-related cancers and metabolic processes.
The GSTM1 gene encodes an enzyme that detoxifies harmful substances like drugs and toxins. The homozygous genotype results in a deleted, non-functional gene, which may increase susceptibility to certain cancers and chemical sensitivities.
Cardiovascular health refers to the overall well-being of the heart and blood vessels. Conditions such as cardiovascular disease (CVD), including artery blockage (atherosclerosis), are characterised by the buildup of fatty deposits, cholesterol, and other substances on the walls of arteries. This process narrows and hardens the arteries, reducing blood flow to vital organs and increasing the risk of heart attack, stroke, and other complications. Contributing factors to poor cardiovascular health include high levels of LDL cholesterol, elevated triglycerides, chronic inflammation, high blood pressure, smoking, and insulin resistance.
Metabolic health and weight management encompass the body’s ability to efficiently convert food into energy while maintaining a healthy balance of hormones, blood sugar, and lipid levels. Common metabolic conditions include type 2 diabetes, hypothyroidism, liver disease, and obesity, all of which are linked to an increased risk of cardiovascular disease and other chronic illnesses. Poor metabolic health can result in weight gain, fatigue, and difficulty maintaining energy balance. Key contributors include a sedentary lifestyle, poor diet, hormonal imbalances, and chronic inflammation.
Genes such as HLA, PEMT, MTR, and LCT can dictate how your body handles specific foods, potentially leading to conditions like lactose intolerance, inflammatory bowel disease, and IBS (irritable bowel syndrome). Genetic variations such as VDR, PEMT, and MTR can also lead to vitamin deficiencies or malabsorption issues, impacting your overall well-being. These imbalances can cause digestive discomfort, nutrient absorption, and inflammation. The myDNA Comprehensive Check can help pinpoint these variations, guiding you to make smarter dietary choices.
Emotional and psychological health is controlled by neurotransmitters, hormones, and neural networks in the brain, which regulate mood, stress, and emotional responses. Genetic factors and clinical biomarkers can impact neurotransmitter and hormone levels contributing to problems like anxiety, depression and stress. The PEMT gene affects brain health, while the COMT gene influences the breakdown of dopamine, affecting mood and cognitive function. Variants in these genes can lead to mood swings, anxiety, and other emotional challenges. The myDNA Comprehensive Check can help you understand these genetic factors, guiding you toward optimal mental and emotional well-being.
Cognitive function relies on neural connections and the interplay of neurotransmitters, hormones, and other brain chemicals. These elements influence stress responses, mental alertness, focus, motivation, memory, learning, and problem-solving. Factors such as genetic variations (e.g. in the PEMT, COMT, and APOE genes), elevated homocysteine levels, vitamin B12 deficiency, poor sleep, lack of exercise, and chronic stress can negatively impact cognitive performance. The myDNA Comprehensive Check identifies genetic predispositions in these areas, aiding in assessing risks for cognitive decline and chronic inflammation.
Strength, stability, and athletic performance rely on the coordinated function of muscles, joints, and bones to support movement and endurance. Bone health plays a crucial role in this balance, as strong bones provide the necessary framework for muscle attachment and joint stability. Weak bones, due to conditions like osteoporosis or low bone density, can increase the risk of fractures and limit physical performance. Similarly, muscle weakness, joint instability, or poor flexibility can compromise overall stability and performance.
Immune health plays a vital role in protecting the body from infections and maintaining overall balance, while inflammation is the body’s natural response to injury or illness. However, chronic inflammation and immune dysregulation can lead to the development of inflammatory and autoimmune conditions, such as rheumatoid arthritis, lupus, or inflammatory bowel disease. These conditions arise when the immune system mistakenly attacks healthy tissues, causing persistent pain, fatigue, and other health complications.
Hormone & Reproductive Health refers to the balance of hormones that regulate the reproductive system, influencing fertility, menstrual cycles, and overall reproductive function. Hormonal imbalances, such as irregular levels of oestrogen, progesterone, or testosterone, can lead to conditions like infertility, polycystic ovary syndrome (PCOS), and endometriosis. Maintaining hormone balance through lifestyle changes, nutrition, stress management, and, if necessary, medical intervention can support reproductive health and fertility.
This genetic methylation test includes the essential MTHFR, COMT, MTRR, MTR, MTHFD1, PEMT, CBS, and AHCY methylation genes. Knowing your methylation genotype can uncover needs for nutritional support such as amino acids, vitamins, and minerals and help guide dietary and lifestyle treatment plans.
This cheek swab test measures:
The MTHFR enzyme is essential for processing folate and converting homocysteine into methionine. Individuals with this mutation may have higher homocysteine, though the effects depend on whether they have one or two copies of the mutation.
This mutation can also reduce the efficiency of the MTHFR enzyme. While its impact is typically less severe than the C677T mutation, having one or two copies of A1298C may impact neurotransmitter and hormone production and contribute to oxidative stress.
The CBS gene helps convert homocysteine into important substances for our body, like proteins and antioxidants that fight cell damage. Mutations in this gene can weaken this process, potentially raising homocysteine levels.
The methionine synthase enzyme is required to convert homocysteine to methionine. The mutation may reduce enzyme efficiency, potentially contributing to elevated homocysteine levels, especially when combined with other genetic or nutritional factors.
This gene encodes an enzyme essential for regenerating methionine synthase. Similar to MTR, mutations in this gene may impair enzyme function, potentially leading to elevated homocysteine levels.
MTHFD1 helps convert folate from one form into another which is critical for methylation. Mutations in MTHFD1 may result in lower levels of active folate as well as folate intermediates, which are a key input for crucial making DNA and RNA, and downstream biological pathways.
This mutation is associated with lower choline production in the liver. Choline is essential for production of acetylcholine which helps send messages through to various organs, ensuring smooth communication within our nervous system and proper functioning of our organs.
Similar to PEMT C744G, this mutation is also associated with lower choline production in the liver. Both PEMT variations can lead to lower phosphatidylcholine levels, which may increase the risk of fatty liver disease and issues with fat metabolism.
A COMT mutation can change how quickly your body breaks down dopamine, adrenaline, and noradrenaline – this can affect neurological systems that regulate mood, cognitive function, and stress.
The AHCY gene is involved in a process called the methionine cycle, which plays an important role in the metabolism of the amino acid methionine.
The AHCY gene is involved in a process called the methionine cycle, which plays an important role in the metabolism of the amino acid methionine.
Your methylation profile describes your body’s ability to regulate methylation, a vital process affecting DNA repair, detoxification, neurotransmitter balance, and cardiovascular health. Imbalances can result in undermethylation which is linked to high histamine, detox challenges, and depression, or overmethylation which is associated with low histamine, anxiety, and mood instability. Poor methylation may also elevate homocysteine levels, increasing the risk of cardiovascular disease and impaired cognitive function.
Methylation plays a key role in cardiovascular health by regulating processes essential for heart and blood vessel function. Methylation also helps produce nitric oxide which relaxes blood vessels to improve blood flow, supports fat metabolism and repairs cardiovascular cells. Methylation defects (specifically MTHFR, MTR, MTRR or CBS) can raise blood homocysteine levels – homocysteine is an inflammatory byproduct with no useful role in the body. Elevated levels of homocysteine can increase the risk of heart attack and stroke, and in rare cases drive whole-body inflammation.
Methylation is essential for brain health through its effects on neurotransmitter production, brain cell repair, and inflammation regulation. Elevated homocysteine levels are linked to brain inflammation, oxidative stress, and an increased risk of neurodegenerative diseases. This test highlights genetic inefficiencies in these areas, helping you understand your risk factors for cognitive decline or chronic inflammation.
Sleep onset, maintenance and quality can be influenced by genetic variations in the PEMT and COMT genes. These genes play crucial roles in neurotransmitter regulation and sleep-wake cycles. Variations in these genes can disrupt neurotransmitter balance, leading to difficulties falling asleep and staying asleep. Knowing your genetic profile can help you optimise your nutrient intake and lifestyle to enhance sleep quality.
Methylation supports gut health by regulating the genes involved in digestion, inflammation, and gut barrier function. Proper methylation helps maintain the integrity of the intestinal lining, preventing “leaky gut”. Methylation also influences the production of neurotransmitters like serotonin, which play a key role in gut-brain communication. Impaired methylation can lead to inflammation, increased nutrient demand, poor nutrient absorption, and imbalances in the gut microbiome, affecting overall digestive health.
Methylation is crucial for energy production as it influences the function of mitochondria, the cell’s powerhouses. Methylation defects can impair mitochondrial function, leading to reduced energy production and fatigue. Methylation also plays a vital role in detoxification processes, particularly in the liver – genetic variations can compromise the liver’s ability to efficiently eliminate toxins, causing their accumulation and potential health issues.
Methylation plays a crucial role in regulating immune response and cellular repair. Abnormal methylation patterns can disrupt immune regulation, causing the body to attack its own tissues and contributing to autoimmune diseases. Poor methylation can also reduce the body’s ability to combat oxidative stress, leading to inflammation and tissue damage. Identifying genetic variations that affect methylation helps assess your predisposition to inflammatory, autoimmune, and oxidative stress-related conditions.
Your cheek swab test kit and all instructions are posted directly to you – there is no need to visit a collection centre.
Mail your sample back to the lab using the prepaid envelope and packaging provided.
Results for this test typically available in 2 weeks and will be published in your online dashboard.
